High sodium intake is associated with increased vascular reactivity and growth, and myocardial fibrosis, which is associated with myocardial disarray.
2.
ST2 is an active participant in the cardiac remodeling pathway and could identify which patients will respond to Eplerenone, or other therapies that reverse myocardial fibrosis.
3.
Cardiac " diastolic function was better in subjects who practiced strict CR for 3 15 years than that in healthy age-and sex-matched control subjects . . . CR subjects had less ventricular stiffness and less viscous loss of diastolic recoil, both of which would be consistent with less myocardial fibrosis . " These effects, in combination with other benefits of CR, such as protection against obesity, diabetes, hypertension, and cancer, suggest that CR may have a major beneficial effect on health span, life span, and quality of life in humans ."
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